Other articles on PubMed by:
MAPRJ - Abstract

Analgesic and anti-inflammatory activities of Asena, a herbal preparation for treatment of arthritis, using rodent models

 

Kofi Donkor1*, Stephen Antwi1,JerryAsiedu-Larbi1, Nutifafa Takyi1, Nii Orleans Martey1 and Laud Kenneth Okine2

 

Research Article | Published December 2013

Medicinal and Aromatic Plant Research Journal, Vol. 1(2), pp. 20-29

 

 

1Department of Pharmacology/Toxicology, Centre for Scientific Research into Plant Medicine, P. O. Box 73, Mampong-Akuapem, Ghana.

2Department of Biochemistry, University of Ghana, Legon, Ghana.

 

*Corresponding author. E-mail: kn.donkor@gmail.com.  Tel: +233 205 240 830

…………………………………………………………………………………………………………..........……

 

View Full Text - PDF

 

The analgesic and anti-inflammatory activities of Asena, a herbal decoction for the treatment of arthritis, were assessed in various murine models. The analgesic activity was evaluated using the yeast-induced mechanical hyperalgesia, hot plate, acetic acid abdominal constriction and formalin tests while the anti-inflammatory effect was assessed in the carrageenan-induced paw edema test. The possible involvement of the opioidergic system in the analgesic activity was also carried out in the acetic acid writhing test. The results showed that Asena possesses potent (p < 0.05) analgesic and anti-inflammatory activities in all the test models employed in the current study. Systemic administration of naloxone, a non-selective opioid receptor antagonist, reversed the analgesic activity of Asena in the abdominal constriction test. It could be concluded that Asena has analgesic and anti-inflammatory effects which may be mediated via both peripheral and central mechanisms. The analgesic activity possibly involves the opioidergic system. These findings thus support its ethnomedicinal use and the anecdotal claims for its use in the treatment of arthritis.

 

Keywords: Analgesic, anti-inflammatory, Asena, morphine, opioidergic system.

 

………………............………………………………………...........……………………………………………

Citation: Kofi D, Stephen A, Jerry A, Nutifafa T, Nii OM, Laud KO (2013). Analgesic and anti-inflammatory activities of Asena, a herbal preparation for treatment of arthritis, using rodent models. Med. Aromat. Plant Res. J. 1(2): 20-29

…………………………………......................……………………………………………………………………