Sub chronic toxicity studies of Asena, a poly-herbal formulation for the treatment of arthritis in rat.

 

Kofi Donkor^1*, Stephen Antwi¹, Jerry Asiedu-Larbi¹, Nutifafa Takyi¹ and Laud Kenneth Okine²

 

Research Article | Published March 2014

Medicinal and Aromatic Plant Research Journal, Vol. 2(1), pp. 18-27

 

 

¹Department of Pharmacology and Toxicology, Centre for Plant Medicine Research, Mampong-Akuapem, Ghana.

²Department of Biochemistry, Cell and Molecular Bology, University of Ghana, Legon, Ghana.

 

 

*Corresponding author. E-mail: kn.donkor@gmail.com.  Tel: +233 205 240 830.

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Sub chronic toxicity studies of Asena, a poly-herbal formulation for the treatment of arthritis in Ghana, was carried out in the rat. In the sub chronic studies, rats were administered with Asena at 60, 600 and 1200 mg/kg daily for six weeks. Urinalysis, hematological and biochemical analyses were carried out on urine; blood and serum samples collected at the end of the six weeks treatment. Histological analysis of the liver, heart, kidney and lung tissues were also done at the end of the treatment period. The results showed that, there were no significant differences (p < 0.05) in the urinalysis and biochemical analyses in Asena-treated animals compared to controls over the treatment period. Similarly, the administration of Asena to experimental rats did not adversely affect hematological indices assayed except platelets which were significantly elevated (p > 0.05) in the treatment groups compared to controls. There was no noticeable morphological change in liver, kidney, lung and heart micrographs of Asena-treated and control animals. In conclusion, it can be said that prolonged administration of Asena may not affect the normal growth nor cause organ specific toxicity in the rat. These findings support its continual use and at least provide a basis for its assessment in clinical trials.

 

Keywords: Phytomedicine, Asena, sub chronic, micrograph, biochemical, hematological, herbal.

 

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Citation: Donkor K, Antwi S, Asiedu-Larbi J, Takyi N, Okine LK (2014). Sub chronic toxicity studies of Asena, a poly-herbal formulation for the treatment of arthritis in rat. Med. Aromat. Plant Res. J. 2(1): 18-27.

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